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We conducted this study to clarify the effectiveness of aspiration endoscopic mucosal resection (EMR) using a cap-fitted scope for early gastric cancer in the C and M regions of the stomach. E M R was performed in 1 1 1 early gastric cancer patients with 123 lesions in the C and M regions. The patients were divided into three groups. The EMR-1 CS group consisted of patients who had undergone E M R with a one-channeled scope, the EMR-2CS group those who had received E M R in which a two-channeled scope was utilized. The E M R C group consisted of patients who had undergone aspiration E M R with a cap-fitted scope.The rate of complete resection improved to a statistically significant degree in the E M R C group in comparison with that in the E M R -1 C S group. In type Ilc, a statistically significant improvement was achieved in the E M R C group in comparison with the EMR-2CS group. In the M region or in lesions 1 0 mm or less in diameter, the rate of complete resection improved in the E M R C group as compared with that in the EMR-2CS group. Our results suggest that E M R C is useful for lesions of early gastric cancer in the C and M regions. (Dig Endosc 1998; 1 0 : 3 1 -3 6 )