The bicyclo[4.3.1]decenone core of the ras-farnesyl protein transferase inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.