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The purpose of this study was to examine the phytochemical content and antioxidant activity of Coptosapelta flavescens Korth root extract obtained from various places. Phytochemical screening, antioxidant activity testing using DPPH radical reduction, color reaction (ABTS), iron reduction (FRAP), reduction capacity technique (RP), and total antioxidant capacity (TAC). The phytochemical tests revealed that C. flavescens water and ethanol extract included alkaloids, coumarins, terpenoids, tannins, and flavonoids. The antioxidant activity results revealed that raw material samples gathered directly in the wild in Ninh Son district (Ninh Thuan province, Vietnam) were more effective than those purchased at the local market with EC50 times value. DPPH, ABTS, FRAP, RP, and TAC techniques yielded 56.02 µg/ml, 54.12 µg/ml, 15.9 µg/ml, 44.85 µg/ml, and 110.94 µg/ml, respectively. The antioxidant impact of raw material samples obtained in Bac Ai district (Ninh Son province, Vietnam) was lower but overall better than that of samples gathered at the local market.

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