Studies in growth chambers indicated that CGA-43089 {α-[(cyanomethoxy)imino] benzeneacetonitrile} applied at a rate of 1.25 g/kg of seed reduced the phytotoxicity of metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide], bensulide [o,o-diisopropyl phosphorodithioateS-ester withN-(2-mercaptoethyl) benzenesulfonamide], EPTC (S-ethyl dipropylthiocarbamate), UBI-S734 {2-[(1,2,5-dimethylphenyl)ethylsulfonyl] pyridineN-oxide} and MBR-18337 {N-[4-(ethylthio)-2-(trifluoromethyl)phenyl] methanesulfonamide} to grain sorghum [Sorghum bicolor(L.) Moench] during seed germination and seedling emergence. The protected sorghum tolerated metolachlor over a wider range of rates than it tolerated the other herbicides. CGA-43089 did not protect sorghum from the phytotoxicity of trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine). Of seven other oximes tested as seed treatments, dimethylglyoxime, benzophenone oxime, pyridine-2-aldoxime, benzoin-α-oxime, and methyl thioacetohydroxamate showed promise for increasing the tolerance of grain sorghum to metolachlor. In general, higher rates of these oximes than the rate of CGA-43089 were required for equivalent protection of sorghum.