Objectives: Purpose of the study evaluation of the cosmetic effect using patches by the company “Aganyan” for facial rejuvenation. Materials and Methods: The study was carried out in 106 participants with presence of perioral wrinkles of the skin. Participants applied four patches (2 copper and 2 zinc) on the face in the area of wrinkles crosswise according to the instructions. The patches were applied for eight hours every third day for three months. Perioral wrinkles were assessed by comparing photographs at the beginning and at the end of the study for each individual case. The efficacy was assessed according to the International Global Aesthetic Improvement Scale (GAIS). Visual confirmation of clinical improvement was also obtained by Life Viz 3D camera pictures. Results: After analyzing the photographs taken before and after using the patch and a personal conversation with each participant, the following data were obtained from participants: • a decrease in puffiness and dark circles under the eyes was noted: 6 out of 15 men, 34 out of 91 women; • smoothing of small mimic wrinkles was noted: 24 women out of 106 people; • lifting of the face oval was noted: 14 women out of 106 people. Evaluation of the effectiveness of the GAIS procedure on M03 and M05, 2/3 of patients had significant mprovement as assessed by physician and participants according to GAIS. Most of the patients also showed significant improvement at visit M12. After analyzing the photographs taken before and after the experiment, and a personal conversation with each patient of the cosmetology profile, the following results were obtained: in 38% of patients, puffiness and dark circles under the eyes decreased, in 23% of participants fine facial wrinkles were smoothed, in 12% of participants the oval of the face was tightened. Our results suggest that patches by the company “Aganyan” can serve as a novel therapy for controlled skin rejuvenation, effective wrinkles and folds. Conclusion: The results of the studies provide a basis for concluding that the method of skin. The patches by the company “Aganyan” have proven its effectiveness through electrical stimulation with low intensity current in patients in different age groups, the study revealed a large number of positive cosmetic effects.