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Purpose: The role of chemotherapy (CT) and radiotherapy (RT) for management of extraskeletal osteosarcoma (ESOS) remains controversial. We examined disease outcomes for ESOS patients and investigated the association between CT/RT with recurrence and survival. Patients and methods: Retrospective review at 25 international sarcoma centers identified patients ≥18 years old treated for ESOS from 1971 to 2016. Patient/tumour characteristics, treatment, local/systemic recurrence, and survival data were collected. Kaplan-Meier survival and Cox proportional-hazards regression and cumulative incidence competing risks analysis were performed. Results: 370 patients with localized ESOS treated definitively with surgery presented with mainly deep tumours (n = 294, 80%). 122 patients underwent surgical resection alone, 96 (26%) also received CT, 70 (19%) RT and 82 (22%) both adjuvants. Five-year survival for patients with localized ESOS was 56% (95% CI 51%-62%). Almost half of patients (n = 173, 47%) developed recurrence: local 9% (35/370), distant 28% (102/370) or both 10% (36/370). Considering death as a competing event, there was no significant difference in cumulative incidence of local or systemic recurrence between patients who received CT, RT, both or neither (local p = 0.50, systemic p = 0.69). Multiple regression Cox analysis showed a significant association between RT and decreased local recurrence (HR 0.46 [95% CI 0.26-0.80], p = 0.01). Conclusion: Although the use of RT significantly decreased local recurrences, CT did not decrease the risk of systemic recurrence, and neither CT, nor RT nor both were associated with improved survival in patients with localized ESOS. Our results do not support the use of CT; however, adjuvant RT demonstrates benefit in patients with locally resectable ESOS.

Although more patients need to be monitored to assess the clinical and functional outcomes of CIRT for patients with chondrosarcoma of the pelvis, this treatment might offer an acceptable alternative.

This paper focuses on the voltages electromagnetically induced by the multiple return strokes involved in a triggered lightning on an overhead power line and a vertical signal line of an automatic weather station (AWS), and the backflow currents and residual voltages in a surge protection device (SPD) embedded in the power line. Pulses of voltage on the overhead power line corresponding to the return strokes with the peak currents ranging from −6.67 to −26.47 kA showed bipolar features. Subpeaks and main peaks ranged from 0.99 to 4.47 kV and from −4.98 to −10.31 kV, respectively. The voltage waveforms corresponding to the return strokes on the vertical signal line of wind speed were of two types: with and without a subpeak after the main peak. All the main peaks, with the peak value from −0.41 to −3.10 kV, were ‘V’ shaped. A significant relationship exists between the peak currents of the return strokes and the 10–90% average gradients of the voltages. The peaks of currents through the SPD ranged from −0.22 to −1.64 kA. The durations of residual voltages ranged from 0.6 to 5.9 ms, average value being 2.1 ms. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.