High collagen type XI alpha 1 (COL11A1) levels are associated with tumor progression, chemoresistance, and poor patient survival in several cancer types. MicroRNAs (miRNAs) are dysregulated in multiple cancers, including epithelial ovarian carcinoma (EOC); however, the regulation of COL11A1 by miRNAs in EOC remains unclear. We examined the role of miRNAs in regulating COL11A1 expression. We identified miR-509 and miR-335 as the candidate miRNAs through an online database search. EOC cell treatment with miR-335 mimics abrogated COL11A1 expression and suppressed cell proliferation and invasion, besides increasing the sensitivity of EOC cells to cisplatin. Conversely, treatment with miR-335 inhibitors prompted cell growth/invasiveness and chemoresistance of EOC cells. miR-335 inhibited COL11A1 transcription, thus reducing the invasiveness and chemoresistance of EOC cells via the Ets-1/MMP3 and Akt/c/EBPβ/PDK1 axes, respectively. Furthermore, it did not directly regulate PDK1 but increased PDK1 ubiquitination and degradation through COL11A1 inhibition. In vivo findings highlighted significantly decreased miR-335 mRNA expressions in EOC samples. Furthermore, patients with low miR335 levels were susceptible to advanced-stage cancer, poor response to chemotherapy, and early relapse. This study highlighted the importance of miR-335 in downregulating COL11A1-mediated ovarian tumor progression, chemoresistance, and poor survival and suggested its potential application as a therapeutic target.

In this paper, we discussed the motion blur behavior relates to MPRT in the strobe backlight LCD for the VR application. The specific equal-intensity band was observed and was explained by the temporal integration model. After optimizing the flash timing of backlight, less than 4 ms of MPRT was measured in our ultra high resolution LCD.

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A 2-inch LCD with a moving picture response time (MPRT) of 1.1 ms and 0.9 ms at 75Hz and 90Hz frame rates was demonstrated by optimizing the timing of the global backlight technology. Such a fast MPRT for an LCD presents a CRT-like display with crystalclear motion-image quality.

Robot artificial limbs has six degrees of freedom. elbow tilting mechanism is driven by a through type linear motor. To determine the elbow installation structure of driven by linear motor, this paper uses the optimization design method, to determine the structure design of the optimization variables, the structure of the motion mathematical model is established, design constraints and objective function is constructed, the comprehensive optimal solutions is gotten by the optimization-algorithm of compound form. Finally, the optimization results is exported and the kinematic simulation graphics is drawed. Considers various factors, From the motor installation space, motor drive efficiency, forelimbs movement range to driving moment , obtains the optimal solution and proves the rationality of the design.