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Our study showed a high selectivity of (18)F-CDP2230 for CYP11B2 over CYP11B1 with a favorable biodistribution for imaging CYP11B2. (18)F-CDP2230 is a promising imaging agent for detecting unilateral subtypes of primary aldosteronism.

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Background: A lys141Asn (K141N) missense mutation in heat shock protein (HSP) B8 causes distal hereditary motor neuropathy (HMN). Results: HSPB8 K141N transgenic mice exhibited mild hypertrophy and apical fibrosis as well as slightly reduced cardiac function. Conclusion: A single point mutation of HSPB8, such as K141N, can cause cardiac disease. Significance: The cardiomyopathy phenotype was observed in cardiac-specific HSPB8 K141N transgenic mice.