P-Keto-P-sulfonylenamines 2a,b reacted with benzamidine or guanidines to give 2,4-disubstituted 5-methanesulfonylpyrirnidines 3a-d, whose rnethanesulfonyl groups were substituted by n-butyllithium or alkylrnagnesiurn bromides to yield 2,4-disubstitued 5-alkylpyrirnidines 6a-d. 2-Substituted 4-amino-5-sulfonylpyrimidines 7a,b, 8 and 2-substituted 5-benzenesulfonylpyrimidin-4-ones 9a,b were similarly obtained from (3-cyano-P-sulfonylenarnines 2c,d and @-ethoxycarbonyl-P-sulfonylenamine (2e), respectively.

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The sulfonyl ketones (I) react with the dimethylformamide acetal (II) to produce the enamines (III).