The present study was conducted to investigate the relationship among perceived social disconnectedness, low frustration tolerance and coping with uncertainty in mothers of children diagnosed with cerebral palsy. The current study used correlational research design. Hundred participants were collected through non-probability purposive sampling technique. Data was drawn from both government and private special education centers of Lahore within six months. Perceived social disconnectedness scale, low frustration tolerance checklist and coping with uncertainty scale were used to measure variables under study. Correlational analysis showed highly significant negative association of social disconnectedness and low frustration tolerance with coping with uncertainty. Findings also showed significant predicting role of social disconnectedness and low frustration tolerance on coping with uncertainty in mothers of children diagnosed with cerebral palsy. Keywords: Perceived Social Disconnectedness, Low Frustration Tolerance and Coping with Uncertainty, CP Child’s Mothers