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The chemical compositions of the water-distilled essential oil of Stachys cretica ssp. lesbiaca Rech. fil. and S. cretica ssp. trapezuntica Rech. fil. were determined by GC and GC-MS. Altogether 63 compounds were identified. The sesquiterpene hydrocarbon, germacrene D (20.3% and 12.9% respectively) was the main component identified in both oils. Furthermore, ethanol, light petroleum, dichloromethane, ethyl acetate and n-butanol extracts prepared from the aerial parts of the plants were tested for their antimicrobial activities against six bacterial strains and the yeast Candida albicans. The extracts exhibited no antibacterial activity, but the light petroleum and n-butanolic fractions showed low antifungal activities. Crude ethanolic extracts of the two subspecies were tested for their ability to inhibit the growth of HL-60 and Ishikawa human tumor cell lines. The IC 50 values were 100 μg/mL for the HL-60 cell line and 200 μg/mL for the Ishikawa cell line.

Synthesis and Biological Evaluation of Dialkylaminoalkylamino Benzo[c][1,7] and [1,8]Phenanthrolines as Antiproliferative Agents. -Title compounds (IV) as well as its [1,8]-regioisomers display more potent cytotoxicity toward L1210 cells than the unsubstituted parent compounds, associated with strong DNA interaction. The introduction of a dialkylaminoalkyl chain in the pyridine cycle A results in an increase of antiproliferative activity of about one order of magnitude, compared to the parent compounds. However, the TopoI inhibitory activity remains low, suggesting that other cellular targets could be responsible for antiproliferative activity. -(SERBETCI, T.; GENES, C.; DEPAUW, S.; PRADO, S.; POREE, F.-H.; HILDEBRAND, M.-P.; DAVID-CORDONNIER, M.-H.; MICHEL, S.; TILLEQUIN*, F.; Eur.

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