Our study results demonstrated that, high RDW, high CK-MB, and absence of preinfarction angina were found to be independent predictors of impaired CCC.

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Ischemia–reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia–reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia–reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia–reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubule-associated protein light chain 3, LC3) can be evaluated among these indicators.

The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion. ÖzBu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

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