AIm:The aim of the present study is to analyze the effects of the MRI features on the recurrence time and prognosis, and to emphasize the analyses of mortality risks in malignant astrocytomas. mAterIAl and methOds:The effects of preoperative MRI features on prognosis were studied for follow-up period of 45 months, from November 1999 to August 2003, on a total of 79 patients' 41 cases of total resection and 38 cases of subtotal resection diagnosed to have malignant astrocytoma subsequent to craniotomy. results:The cases of gross total resection had 2.2 times as high survival rate as those in the subtotal resection group (p<0.01). The comparison of the cases in the groups in relation to their ages revealed that mortality rate rose 4.35 times (p<0.01) in the age group of 60 years and above, and 2.1 times in the age group of 45-59 years. When cases without necrosis were compared with the group containing necrosis of grade 1, 2, 3, it was observed that the probability of mortality increased 3.84 (p<0.01), 4.15 times (p<0.01) in the case of necrosis of grade 2 and 3, respectively by means of Cox regression model. BulGulAr: Cox regresyon analizinde; gross total rezeksiyon yapılan olguların subtotal rezeksiyon grubuna göre 2,2 kat hayatta kalma olasılığına sahip olduğu görüldü (p<0,01). Yaş gruplarında ise, 60 ve üzeri yaş grubundaki olguların ölüm olasılığının 4.4 kat arttığı (P<0.01), ölüm olasılığındaki bu artışın 45-59 yaş grubunda 2,1 kat olduğu tespit edildi. Nekroz içermeyen olgular 1, 2 ve 3. derece nekroz içeren grupla karşılaştırıldığında; 2. derece nekroz içeren grupta ölüm olasılığının 3,84 kat arttığı (P<0,01), 3. derece nekroz içeren grupta ise ölüm olasılığının 4,15 kat (p<0,01) arttığı görüldü. sOnuÇ: Malign astrositomalarda Preoperatif MRI'daki nekroz hastalığın prognozu açısından önemli bir klinik belirleyici olarak görünmektedir.

A novel azo derivative, 2,3,4,6 -tetrahydroxy-3 -sulfoazobenzene (THSA), was synthesized by using pyrogallol. The acid dissociation constants, or K a values, of THSA were determined by the UV-visible spectroscopic technique. The protonation and deprotonation behaviors of the title molecule were studied from the super basic to the super acid region (i.e. 10 N NaOH to 98% H 2 SO 4) , including the pH region. A selective and sensitive UV-visible spectrophotometric method was devised for determination of aluminum by using this ligand. The developed method was successfully applied to an alunite mineral and to pharmaceutical preparations for the determination of aluminum.

A series of new 4-(3,4-dimethoxyphenethyl)-5-akyl/aryl-2H-1,2,4-triazol-3(4H)-ones (3a-g) was obtained by the reaction of ethyl 2-(ethoxy)(alkylidene/arylidene)hydrazinecarboxylate (1) and 2-(3,4-dimethoxyphenyl)ethanamine (2). Compounds 4a-f and 5 were synthesized from the reaction of corresponding compounds 3a-f and 3g with BBr 3 , respectively. With elemental analysis, IR, 1 H-NMR, and 13 C-NMR spectral data, 14 newly synthesized compounds were characterized. The structure of compound 3a was inferred through IR, 1 H-and 13 C-NMR, elemental analysis, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4a, 4c, 4d, 4f, and 5 exhibited the highest degree of antioxidant activity.

Prostate carcinoma, when metastatic, typically involves bone and produces both osteoblastic and osteolytic changes. A 73-year-old man was admitted to our department because of unilateral progressive proptosis and visual blurriness for 3 months. The patient had a history of prostate adenocarcinoma diagnosis 5 years ago. We report a case of orbital involvement presented that intraorbital mass (including periocular structures), temporal bone and temporal muscle from prostate cancer. The mass was removed with total excision. Despite the frequency of bone metastasis in prostatic carcinoma, triple orbital metastases are extremely rare. The best of our knowledge, prostate adenocarcinoma and its triple (temporal bone, temporal muscle and intraorbital mass) orbital metastases have not been published previously. Metastatic orbital tumor secondary to prostate cancer should be considered in patients who have varying degrees of eye symptoms.