Different benzaldehydes and pyridine substitution were used on 1 and 4 'N'-positions of thiosemicarbazide respectively. This substituted-benzaldehyde-2-aminopyridine-N-thiohydrazone ligand was further used to synthesize Co(II), Ni(II) and Co(II) based metal complexes and characterized by FT-IR, Elemental analysis, ESI Mass and elemental analysis. All synthesized compounds were studied for their physical properties, antibacterial and antifungal activity. In this antimicrobial study Cu(II) and Ni(II) metal complexes have shown better anti-bacterial activity. While several synthesized metal complexes have shown comparable activity with standard drugs taken.

ABSTRACT1,5-benzodiazepines have been synthesized by Nano Zirconia and Nano Sulfated Zirconia in solvent free conditions. Synthesis was carried out by conventional as well as microwave method. Benzodiazepines were synthesized by reacting o-phenylenediamine and few ketones in the presence of catalytic amount of Nanoparticles. Particles used were sized in between 53-100 nm. Nanoparticles were characterized by FT-IR, DLS and powder XRD analysis.

1,5-benzodiazepines have been synthesized by Nano Zirconia and Nano Sulfated Zirconia in solvent free conditions. Synthesis was carried out by conventional as well as microwave method. Benzodiazepines were synthesized by reacting o-phenylenediamine and few ketones in the presence of catalytic amount of Nanoparticles. Particles used were sized in between 53-100 nm. Nanoparticles were characterized by FT-IR, DLS and powder XRD analysis.