Coronary heart disease has a significant impact on functional status and quality of life. Selfefficacy plays a crucial role in self-care management for patients with coronary heart disease. The primary objective of this study was to examine the relationship between self-efficacy and quality of life in patients with coronary heart disease. A cross-sectional design was employed, and a sample of 100 patients with coronary heart disease was recruited through consecutive sampling from the Cardiology Department of the Regional General Hospital in Jambi Province. The instruments used in this study included the 6-item Self-Efficacy for Managing Chronic Diseases scale (SEMCD-6) and the World Health Organization Quality of Life Brief Version (WHOQOL-Bref). Data analysis was performed using Spearman correlation. The results demonstrated a positive correlation between self-efficacy and the four domains of quality of life, namely physical, psychological, social relations, and environmental domains (p-value < 0.05). These findings indicate that higher levels of self-efficacy are associated with better quality of life in patients with coronary heart disease. It is recommended that nurses enhance patient self-efficacy through motivation and education, both for the patients themselves and their families, as this can contribute to improvements in their quality of life.