No abstract

Histoplasmosis is a systemic fungal disease caused by dimorphic fungus Histoplasma capsulatum and is more common in immunocompromised patients. We report two cases of disseminated histoplasmosis in immunocompetent individuals from a non-endemic zone in Western India. Rapid diagnostic tests like urinary antigen detection and molecular assays comprise the need of the hour as early initiation of antifungal therapy can be life-saving. Clinicians need to be aware of this entity to prevent misdiagnosis and initiate prompt effective management.

Mucormycosis is a devastating angioinvasive disease caused by fungi belonging to the order Mucorales. These fungi gain entry into the human body via respiratory tract or skin, and less commonly through the gastrointestinal tract. They have a predilection to invade the blood vessels and cause extensive thrombosis and ischaemic tissue necrosis.The three genera of Mucorales-Rhizopus, Mucor and Lichtheimia account for 70-80% of the mucormycosis cases worldwide. Other less frequent genera include Rhizomucor, Apophysomyces, Cunninghamella,