Previously reported enterovirus 71 (EV71) infections associated with hand-foot-mouth disease, aseptic meningitis, encephalitis, polio-like myelitis, and paralysis all have involved young children. We report a 28-year-old woman who possibly contracted EV71 infection during pregnancy. Obstetric ultrasonograms at 25 weeks of gestation revealed an abnormal placenta, as well as hepatosplenomegaly, liver calcification, excessive ascites, and mild hydrocephalus of the fetus. Presence of EV71 was determined by immunodot blotting, virus culture, and partial sequencing of the amplified product of nested reverse transcription-polymerase chain reaction. Postmortem immunohistochemistry further identified EV71 in the fetal midbrain and liver. The findings indicate that intrauterine EV71 infection is possible during pregnancy.

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13th International Congress on Infectious Diseases Abstracts, Poster Presentations e325 strated, CCHF is the most viral hemorrhagic fever in Iran, so with a regular training program for the people and the high risk professions in the endemic areas, the mortality rate of 20% in 2000 was decreased up to nearly 6.5% in 2007. It seems that with a continuous training and informing program, we will also be able to reduce propagation of CCHF in Iran.