Denbinobin inhibited IL-1β-induced ICAM-1/VCAM-1 expression and monocyte adhesion to OA-FLS. It was due to denbinobin increased miR-146a level, which in turn inhibited NF-κB signaling. Our overall findings suggest that denbinobin can be used as a potent anti-inflammatory agent.

A 12-hours rest can largely restore disc dynamic properties during fatigue loading; hence fully recover disc dynamic properties. A long-term fatigue loading squeezes the disc fluid and injures the disc integrity. The 12-hours rest can recover the fluid loss but not the injury of disc. Hence, the disc degradation during the second fatigue loading was faster than the first fatigue loading.

No abstract

No abstract

No abstract