Background:Stenosis in the area of the cricotracheal segment is still a challenging problem to be dealt with. Post-intubational cases mark an increase in recent years due to the advances in intensive care, thoracic surgery and neurosurgery departments.Case Report:This paper describes a case report of a patient with severe subglottic stenosis (grade III according to the Cotton-Myer scale), introduces a new option in cricotracheal resections - postoperative temporary non-cannulated tracheostomy and describes its advantages.Conclusion:This variation of classical operative techniques provides additional fixation of the trachea, thus relieving any transitory tension on the anastomosis; acts as a valve and decreases the air-pressure in the upper airways during coughing and sneezing in the post-operative period; and is an easy access point for video tracheoscopy of the anastomosis.

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Worldwide, laryngeal squamous cell carcinoma (LSCC) is the second most common head and neck cancer (HNC). Advanced forms of LSCC, especially HPV-negative types, frequently involve locoregional lymph node metastasis, which are associated with treatment failure. Despite recent development and improvement in treatment protocols [1], still advanced LSCC is a global oncological burden, associated with challenges and complications. The study group included 60 cases of predominantly HPV-negative tumours with all patients having history of long-term smoking. We found that miR-1246 was significantly dysregulated in advanced LSCC – almost 72% of the patients in the study group showed overexpression of miR-1246 in tumour tissue above relative quantity of 2 (RQ > 2). Additionally, miR-1246 showed significant heterogeneity in expression levels between tumour depth and surface and moreover higher expression levels of the molecule correlated with higher chance of locoregional metastasis. In conclusion, we explored the expression levels of miR-1246 in advanced LSCC and adjacent normal tissue, revealing new tumour heterogeneity characteristic. We demonstrated potential association between miR-1246 expression levels and presence of locoregional lymph nodal metastasis.