FAS is a reliable prognostic marker to predict DFS and OS in patients with early breast cancer.

Intestinal metaplasia identifies Barrett's esophagus (BE) and is associated with an increased risk for esophageal adenocarcinoma. Dysplasia occurs as an intermediate step. However, progression from metaplasia to neoplasia without the demonstration of dysplasia has been described. The role of dual‐parameter flow cytometry (FC) as a predictor of neoplastic risk in dysplasia‐free cases was evaluated. DNA/protein FC and histology were performed on 362 samples from 30 dysplasia‐free BE patients, followed up since 1985 once every 1–2 years. Nine cases were aneuploid, five of which (group IV) were frankly aneuploid; in the other four cases (group III), aneuploidy was detectable by dual‐parameter analysis only. Twenty‐one patients were diploid. Twelve (group II) also had an abnormally high G1‐phase protein content compared to group I (nine patients), which were diploid with a low‐moderate protein content. In three patients of group IV an adenocarcinoma in situ was diagnosed, after 5, 6, and 10 years, respectively. In two patients of group III, a low‐ and a high‐grade dysplasia were observed at 3 and 6 years follow‐up, respectively. One patient of group I first acquired a high protein content, then an aneuploid DNA content, and then progressed to adenocarcinoma (12 years). None of the still diploid patients (17 cases) have progressed to dysplasia or cancer compared with 6 of 13 presently aneuploid patients (P < 0.01). In conclusion, DNA/protein FC is a marker of increased malignant potential and thus may be used to detect patients at higher risk in dysplasia‐free BE and assist in understanding the various stages of malignant transformation in long‐term follow‐up studies. Cytometry (Comm. Clin. Cytometry) 34:257–263, 1998.  © 1998 Wiley‐Liss, Inc.

FAS is a reliable prognosticator of recurrence in poorly differentiated early breast carcinomas. Association of FAS with PLVI may be useful to plan a correct follow-up in patients with breast neoplasms.

The glandular cells of the human endometrium express GH from the late luteal phase throughout pregnancy in the decidual tissue. We suppose that GH plays an important role in blastocyst implantation.

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