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The efficacy of sodium stibogluconate against Leishmuniu donovani infections was markedly enhanced by encapsulating this drug in tuftsin-bearing liposomes. Also, pretreatment of the animals with these liposomes (free of drug) rendered them resistant to this infection, possibly by activating the host's macrophages. These results demonstrate that tuftsinbearing liposomes besides delivering the drug to the target cells could also enhance the nonspecific resistance against infections, thus offering an additional advantage over the use of tuftsin-free liposomes as drug carriers in leishmania therapy.

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The title pyrimidines, e.g. (I), (III), (V), (VII) and (IX), and a variety of azolopyrimidines, synthesized from (V), are tested in vivo as leishmanicidal agents.