Abstract:Background: Preeclampsia is associated with impaired antioxidant defense that results in maternofetal complications. In addition to antioxidant defi ciency, hemolytic disorder has also been observed in preeclamptic mother.Methods: This study aims in analyzing the fetal complications using cord blood RBC (red blood cell); further the antihemolytic and antioxidant effi ciency of two common probiotic yeasts Monascus purpureus and Saccharomyces cerevisiae in preeclamptic and normotensive RBCs were assessed.Results: There was a signifi cant decrease in the antioxidant status (p<0.05) with increased oxidative stress, nitrative stress (p<0.05) and hemolysis (p<0.001) in preeclamptic RBC comparatively. M. purpureus demonstrated a highly signifi cant reactive oxygen radical scavenging activity (p<0.001) whereas S. cerevisiae exhibited a highly signifi cant nitric oxide radical scavenging activity (p<0.001). It was noted that oxidative stress hemolysis was decreased with increased antioxidant level in cord blood RBC from both samples after incubation with both yeasts in a similar manner. The antihemolytic property of M. purpureus and S. cerevisiae suggests that S. cerevisiae functions effi ciently with increasing stress. Conclusion: This study demonstrates for the fi rst time that despite their differential scavenging activities, a diet rich in M. purpureus and S. cerevisiae could equally serve as a good natural supplement to alleviate the stress status in the preeclamptic fetus (Tab. 4, Fig. 1, Ref. 39). Full Text in PDF www.elis.sk.