Objective: In this study, we aimed to evaluate the effect of large prostate volume on surgical, oncological and functional outcomes in prostate cancer patients who underwent Robot-assisted radical prostatectomy (RARP). Material and Methods: In this study, patients who underwent RARP due to prostate cancer by a single surgeon were divided into two groups as large prostate volume over 75 cc (Group-1) and prostate volume less than 75 cc (Group-2), and these two groups were compared retrospectively. Patients who were followed up for 12 months were assessed. Results: There was no significant difference between the two groups in terms of age, preoperative PSA level, clinical stage distributions, Gleason score, D’Amico risk classification, preoperative potency and continence assessment (p>0.05). The operative time was 169.9 ± 62.5 minutes and 145.6 ± 56.1 minutes in Groups 1 and 2, respectively, and was significantly higher in Group 1 (p= 0.02). Bladder neck reconstruction was performed in 17 (35%) and 2 (3%) patients in Groups 1 and 2, respectively, and it was statistically significantly higher in Group-1 (p=0.001). After removal of the urethral catheter in Group 1 and Group 2, full continence and potency rates were similar during the 1-year follow-up (p >0.05). Biochemical recurrence rates at 6 months and 1 year were similar in Group 1 and Group 2 (p >0.05). Conclusion: In prostate cancer patients with large prostate volume, RARP results in longer operative time and bladder neck reconstruction may be required.. However, in operations performed by experienced surgeons, large prostate volume does not have a negative effect on surgical, functional and oncological outcomes. Keywords: robotic surgical procedures, prostatectomy, prostate, organ size

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Kronik böbrek hastalığında böbrek nakil alıcılarında inflamasyon belirteci olarak en sık kullanılan biyomarker CRP olmuş, renal fonksiyonlar ise kreatinin düzeyleri ile takip edilmiştir. Bu çalışmada inflamatuar belirteç olarak B2 mikroglobulin ve pentraksin seviyelerinin renal transplant yapılan hastalarda erken dönemdeki seyrini kaydettik ve inflamasyon belirteci olarak kullanılabilirliğini belirlemeyi amaçladık Gereç ve Yöntemler: Çalışma Ocak-Haziran 2017 tarihleri arasında canlı donörlerden böbrek nakli yapılan 23 yetişkin hasta ile yapılan prospektif bir gözlem çalışmasıdır. Hastaların demografik özellikleri, transplantasyon sonrası ilk gün, 3.gün , 7.gün ve 30.gün kan örnekleri alınarak biyokimya parametreleri ve inflamasyon belirteçleri çalışıldı.Bulgular: Çalışmamıza alınan 23 hastanın 18'i (%78) transplantasyon öncesi diyaliz programındaydı, 5 hasta (% 22) ise preemptif diyaliz aldı. Laboratuar çalışmalarda B2 Mikroglobulin seviyelerinde postoperatif ilk gün 3. Gün ve 7.gün anlamlı düşüşler (p<0,05) izlenmekle beraber 1.hafta ile 1.ay arasında anlamlı fark saptanmadı (p>0.05). Kreatinin seviyeleri ise 3.günde ilk güne göre anlamlı olarak düştüğü izlenirken 1.hafta ve 1.ayda ise anlamlı değişim göstermedi. B2 mikroglobulin ile kreatinin arasında postop 0.gün ile 3.gün, 7.gün ve 1.ayda anlamlı pozitif korelasyon saptandı (p< 0.05). Pentraksin ve CRP seviyeleri ise 3.günde ilk güne göre anlamlı olarak yükseldi sonrasında 7.gün ve 1.ayda anlamlı olarak düştü (P< 0.05). Ancak Pentraksin değişimleri ile CRP değişimleri arasında anlamlı korelasyon saptanmadı.Sonuç: Böbrek transplant alıcılarında infla- AbstractObjective: CRP was the most commonly used marker of inflammation in renal transplant recipients in chronic renal disease, and renal functions were monitored with creatinine levels. In this study, we recorded the early course of B2 microglobulin and pentraxin levels as inflammatory markers in renal transplant patients and aimed to determine its usefulness as markers of inflammation.Materials and Methods: This is a prospective observation study of 23 adult patients who underwent renal transplantation from living donors between January and June 2017. Demographic characteristics, blood samples, biochemical parameters and inflammation markers were studied on the first day, 3rd day, 7th day and 30th day after transplantation.Results: 18 (78%) of the 23 patients included in our study were in the pre-transplant dialysis program and 5 (22%) received preemptive dialysis. There were significant decreases in B2 microglobulin levels on the first postoperative day on the 3rd day and 7th day (p <0.05), but no significant difference was found between the 1st week and the first month (p> 0.05). Creatinine levels decreased significantly on the third day compared to the first day. There was a significant positive correlation between B2 microglobulin and creatinine at postoperative day 0, day 3, day 7 and month 1 (p <0.05). Pentraxine and CRP levels increased significantly on the third day compared to the first day, then de...

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