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To evaluate and compare the effect of different doses of Dexmedetomidine on Heart rate, Blood pressure, oxygen saturation and depth of anaesthesia. This study was done in the Department of Anaesthesiology, Dr. RPGMC, Kangra at Tanda, Himachal Pradesh. This study was carried out on 90 patients in the age group of 20 to 60 years. Patients were ASA I-II, scheduled for open cholecystectomy. Study design-It was a prospective, double blind randomised study. The patients were allocated into one of the three groups by random number chart. The study drug solution was prepared and given to the investigator by a nonparticipant staff. As a result we concluded that Dexmedetomidine effectively attenuates the Extubation response in dose of 0.75µg/kg and 1µg /kg whereas in dose of 0.5µg/kg the Extubation response was not effectively attenuated. However the quality of Extubation was comparable with Dexmedetomidine in dose of 0.75µg/kg and 1µg /kg (p>0.05). So we conclude that 0.75µg/kg is the single best dose of Dexmedetomidine for attenuation of Extubation response.