The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.

The world's ecosystems are losing biodiversity fast. A satellite mission designed to track changes in plant functional diversity around the globe could deepen our understanding of the pace and consequences of this change and how to manage it.The ability to view Earths' vegetation from space is a hallmark of the space age. Yet decades of satellite measurements have provided relatively little insight into the immense diversity of form and function in the plant kingdom in space and time. Humans are rapidly impacting biodiversity around the globe 1,2

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Ecological research produces a tremendous amount of data, but the diversity in scales and topics covered and the ways in which studies are carried out result in large numbers of small, idiosyncratic data sets using heterogeneous terminologies. Such heterogeneity can be attributed, in part, to a lack of standards for acquiring, organizing and describing data. Here, we propose a terminological resource, a Thesaurus Of Plant characteristics (TOP), whose aim is to harmonize and formalize concepts for plant characteristics widely used in ecology. 2. TOP concentrates on two types of plant characteristics: traits and environmental associations. It builds on previous initiatives for several aspects: 1) characteristics are designed following the entity-quality model (a characteristic is modelled as the “Quality” of an “Entity” ”) used in the context of Open Biological Ontologies; 2) whenever possible, the Entities and Qualities are taken from existing terminology standards, mainly the PO (Plant Ontology) and PATO (Phenotypic Quality Ontology) ontologies, and 3) whenever a characteristic already has a definition, if appropriate, it is reused and referenced. The development of TOP, which complies with semantic web principles, was carried out through the involvement of experts from both the ecology and the semantics research communities. Regular updates of TOP are planned, based on community feedback and involvement. 3. TOP provides names, definitions, units, synonyms and related terms for about 700 plant characteristics. TOP is available online (www.top-thesaurus.org), and can be browsed using an alphabetical list of characteristics, a hierarchical tree of characteristics, a faceted and a free-text search, and through an Application Programming Interface. 4. Harmonizing definitions of concepts, as proposed by TOP, forms the basis for better integration of data across heterogeneous data sets and terminologies, thereby increasing the potential for data reuse. It also allows enhanced scientific synthesis. TOP therefore has the potential to improve research and communication not only within the field of ecology, but also in related fields with interest in plant functioning and distribution