Hypertension commonly termed as High blood pressure is a chronic disorder characterized by systolic >140mm Hg and diastolic >90mm Hg. The prevalence of Hypertension is increasing year by year globally as well as in India. Inadequate treatment of hypertension leads to complications such as congestive cardiac failure, stroke, kidney disease and blindness. Conventional hypertensives that have been in use are associated with side effects. Traditional medical systems which are having herbal plants as their formulations plays an important role in reducing high blood pressure with minimizing side effects. There is an increase in the use of herbal therapies to treat non communicable disease is on the rise worldwide. Siddha, one of the traditional medical systems of India, practiced mostly in south India had many formulations for Hypertension. One among them is veppampoo mathirai, a polyherbal tablet formulation, which had been in use, is found to be effective for hypertension. In this regard, this review focuses on the proven scientific antihypertensive related activities of hypertension exhibited by each ingredient of veppampoo mathirai.