Background : Neonatal immune thrombocytopenia, a consequence of transplacental transfer of antiplatelet antibodies can result in serious bleeding with disastrous consequences in the otherwise healthy newborn. Methods : Over 2 years at a service hospital, 5 mothers with chronic autoimmune thrombocytopenia and one with maternal alloimmunisation delivered, which comprised the study sample. Results : Of these, two ladies suffered episodes of thrombocytopenia in the current pregnancy. They were provided platelet transfusions and intravenous immunoglobulins. All patients delivered vaginally. Cord blood platelet was normal in all cases. Three babies developed thrombocytopenia, two due to autoimmune and one alloimmune pathology. The nadir of thrombocytopenia occurred in 36-72 hours with recovery taking place in 10 days. The clinical manifestations were petechiae, ecchymosis, gastric bleed and oozing from vitamin K injection site. Two of the affected babies were provided intravenous immunoglobulins and one steroids. Only one of the two mothers who suffered thrombocytopenia during pregnancy and was provided intravenous immunoglobulins was associated with neonatal thrombocytopenia, an inconsistent relation. It was also observed that antenatally provided immunoglobulins raised effectively maternal rather than fetal platelet counts. However, postnatal immunoglobulins were efficacious in thrombocytopenic neonates. Conclusion : Thus inspite of several therapeutic and preventive modalities being described, the optimum management strategy of immune mediated perinatal thrombocytopenia is yet in evolution.

Introduction:Omenn syndrome, a variant of severe combined immunodeficiency disorder, is a rare condition, with few cases reported in literature. Case Characteristics: A three month old female infant presented with recurrent severe infections, chronic diarrhea, severe erythroderma and lymphadenopathy. Immunological work-up revealed agammaglobulinemia, with both B cell and T cell deficiency. Genetic studies were compatible with Omenn syndrome. Outcome: Bone marrow transplantation was planned, but the infant succumbed to complications. Message: In a young infant with recurrent severe infections, characteristic skin lesions and combined immunodeficiency, Omenn syndrome should be suspected.

Skin diseases can manifest in various ways. Sometimes it can be secondary to underlying systemic disease. In developing countries including India skin diseases are very common but they are being neglected with the thought that they are always benign.Our study is a cross sectional one done to determine the pattern and magnitude of skin diseases. All newly registered patients reporting to Skin OPD of B.K.L.Walawalkar Rural Medical College, Dervan during the period from 1 January 2018 to 31 December 2019 were enlisted in the study. Out of 5090 patients included in our study, ­­52.62% were female patients and 47.38% were males with female to male ratio of 1.11:1. Majority of the patients (21.47%) was from the age group 21-30 years followed by the age group of 11-20 years (19.58%), followed by the age group of 31-40 years (18.52%). Fungal infections constituted the maximum number of the cases (51.53%), followed by Eczema (17.44%). The Acne comprised of (7.19%). Fungal infections comprised majority of cases followed by eczema and allergic disorders in Konkan region of Maharashtra which has a tropical and humid climate. Thus an extensive study may be needed to have a holistic approach to the problem establish a correlation between the variables.

Dermatophytes are aerobic fungi that produce proteases that digest keratin and allows colonization, invasion and infection of the stratum corneum of the skin, the hair shaft, and the nail. This study was an attempt on the part of the author to find out the incidence and various clinico-epidemiological characteristics of Dermatophytosis in skin OPD of Tertiary care Hospital, B.K.L.W.R.M.C., Dervan. The study was carried on 2444 patients of Dermatophytosis attending the OPD, out of which 49.79% of the cases were Tinea Cruris (TC). The age group of 11-20 years showed maximum prevalence of Dermatophytosis (22.17%). 58% of the patients had diffuse lesions. Body involvement was seen in 87% of cases. Itching was the most common condition associated with Dermatophytosis. 35% of the patients reported with family history of Tinea Cruris.Circumscribed variety of TC was found to be most common variant mostly observed in 2and 4 decade, with a male preponderance. Groin was the most common site with multiple lesions. Nail changes was most commonly associated with TC.