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Synthesis and Biological Evaluation of Novel Mannich Bases of 2-Arylimidazo[2,1-b]benzothiazoles as Potential Anticancer Agents. -The novel compounds (VI) are evaluated for their antiproliferative activity in three cancer cell lines. Two promising compounds (VIf) and (VIg) induce G2/M cell cycle arrest with down regulation of cyclin B and up regulation of Chk2 protein. These compounds also show the characteristic features of apoptosis such as enhancement in the levels of caspase-3. Further downstream proteins playing a potential role in cell cycle as well as proliferation are down regulated. -(KUMBHARE*, R. M.; KUMAR, K. V.; RAMAIAH, M. J.; DADMAL, T.; PUSHPAVALLI, S. N. C. V. L.; MUKHOPADHYAY, D.; DIVYA, B.; DEVI, T. A.; KOSURKAR, U.; PAL-BHADRA, M.; Eur. J. Med. Chem. 46 (2011) 9, 4258-4266, http://dx.

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