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New Schiff's base derivatives 5a-j have been synthesized by reaction between 5-aryloxypyrazole-4-carbaldehydes 3a-j and 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide 4 in the presence of nickel (II) nitrate as a catalyst in ethanol at room temperature with good yield (75-88 %). All compounds were tested for antibacterial properties and inhibition of E. coli FabH. Of the compounds studied, the majority of the compounds showed effective antibacterial properties and inhibition of E. coli FabH activity. Compound 5i showed the most effective inhibition (IC 50 = 4.6 ± 0.2 lM) by binding into the active site of the E. coli FabH receptor with minimum binding energy (DG b = -54.2961 kcal/mol). The binding was stabilized by two hydrogen bonds, two p-p, and three p-cation interactions.

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3-(2-Furyl) acrylic acid (FAA) and 2,3-epoxypropyl-3-(2-furyl) acrylate (EPFA) were synthesized. EPFA was characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 HNMR) spectroscopy. Copolymerization of prepared EPFA was carried out with styrene as the comonomer, by varying the mole ratio of EPFA:styrene at different reaction times, using benzoyl peroxide as an initiator at 80 ° C in toluene. FAA, EPFA and copolymers were characterized by FTIR and 1 HNMR spectroscopy, as well as viscosity, gel permeation chromatography (GPC) and epoxy equivalent weight (EEW). Various thermal and kinetics parameters were determined and interpreted in light of the nature of the curing agent, by using two different curing systems, namely, chlorosulfonic acid (ClSO 3 H) at 120 ° C and maleic anhydride/triethanolamine (MAn/TEA) at 160 ° C. Mechanical and electrical properties, as well as chemical resistance of the selected glass fiber reinforced composites, were determined according to the ASTM method and discussed in light of copolymer composites.

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