The usage of Propofol is the most common method for the sake of insertion of I-Gel. But when propofol is used it may cause serious problems like swelling or inflammation at the injection site, low blood pressure, and apnea. There is a need to find another better method for providing anesthetics during the insertion of I-Gel. Objective: To find out the effects of two anaesthetics propofol and sevoflurane during the insertion of I-Gel. Methods: For the sake of the study a group of 66 patients were selected. All of these patients have to go under some surgeries using commonly available an aesthetics. The patients were divided into two groups 33 patients in each group. One group received Propofol before surgery and the other group receive sevoflurane. Then after the insertion of I –Gel, patients were analyzed in detail for all the changes that took place. Results: After the insertion of I-Gel, all the physical changes of the patients were analyzed in detail. Both of the study groups were given different drugs, but after surgery, no difference was observed between two groups having different an aesthetic. Both of the group have same heart rate, blood pressure and other insertion details except that Sevoflurane need much time to perform it’s an aesthetic function as compared to Propofol. Conclusion: After all these experiments, it is inferred that, when the effects of both drugs were compared, Sevoflurance has stability in the case of hemodynamics, it can replace propofol in a number of procedures due to its stability. Propofol does not have so much hemodynamic stability. But when I-Gel insertion has to be performed, Propofol has a better rate of induction as compared to sevoflurane.

Introduction: The thyroid gland is one of the largest endocrine gland constitute of two lobes connected by an isthmus. Thyroid nodules are a frequent clinical problem and its incidence is rising. The solitary nodules are the palpable nodule in otherwise normal gland whereas dominant nodules are the palpable nodule in an enlarged gland. There is a variable frequency of malignancy in solitary cold nodule. Our study is aimed to find its frequency in local population. Objective: To determine the frequency of Malignancy in solitary cold nodule thyroid. Material and Methods: This is the descriptive case series study conducted at East Surgical Ward, Mayo Hospital Lahore in 1 year duration from 01-01-2014 to 31-12-2014. 140 patients age more than 12 years of either sex with confirmed solitary cold nodule thyroid