No abstract

Novel laudanosine dimers in which two laudanosine units are linked at C-2′ via a two or three-carbon linker (alkane, alkene or alkyne) have been prepared using palladium-catalysed cross-coupling reactions (Mizoroki-Heck and Sonagashira reactions). In one example, a second three-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system.

b) exhibit modest antagonistic activity against metabotropic glutamate receptor 2. -(UNG*, A. T.; PYNE, S. G.; BATENBURG-NGUYEN, U.; DAVIES, A. S.; SHERIF, A.; BISCHOFF, F.; LESAGE, A. S.