Libo (ficus variegata blume) have benefits because it contains active compound of flavonoid. Flavanoid could inhibited activation of intestine peristaltic, so that could hinder defecation frequency, decreasing the secretion of fluids and electrolytes. The aims of this research was to understand activity of ethyl acetate fraction of libo fruit as an antidiarrheal in mice (mus musculus). Diarrheal condition was made with induction use oleum ricini (castor oil). Methods used is protection method for castor oil. The results show that ethyl acetate faction of libo fruit was have antidiarrheal activity.