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The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis.

We consider traumatization of the autovenous graft to be the main disadvantage of the known methods of autovenous graft extraction. We have developed instruments for subcutaneous extraction and gentle treatment of autovenous grafts, description and results of their use are given below. For subcutaneous extraction of autovenous grafts we offer an instrument developed by us - atraumatic vein extractor.