An assessment of the situation with import substitution at manufacturing enterprises in the Altai Territory based on an analysis of the effectiveness of foreign purchases carried out by these enterprises is the purpose of writing this article. The authors used the results of studies by Russian and foreign authors on the strategy and tactics of the behavior of enterprises in matters of importing raw materials, materials, technological equipment and technologies under the sanctions regime introduced by the countries of the European Union and the United States in the period 2017-2022, as well as statistical data from Rosstat and Office of the Federal State Statistics Service for the Altai Territory and the Republic of Altai, materials of the Altai Branch of the Russian Union of Industrialists and Entrepreneurs and data from a survey of industrial enterprise managers. Using the example of manufacturing enterprises in the region, the actual situation with import supplies is shown at the present time, an assessment is made of the situation with import substitution at innovatively active enterprises. It that as a result of the import substitution policy, the dependence of has been established manufacturing enterprises on foreign supplies has decreased. Nevertheless, work in this direction now needs to be increased, especially, in the opinion of the interviewed heads of Barnaul enterprises, especially modern technologies and equipment based on the formation and implementation of federal programs for the dynamic development of mechanical engineering.