Objective. To estimate a high-frequency welding of the living tissues as a variant of treatment for the Barrett’s esophagus. Materials and metods. Retrospective analysis of the treatment results was conducted in 73 patients, suffering Barrett’s esophagus, in 36 of whom the argon-plasm coagulation was performed (Group I), while in 37 (Group II) - a high frequency welding of living tissues. Into the investigation the patients with a short-segment Barrett’s esophagus C2-3M3-4 (the Prague Classification, 2004 yr) and a high-grade dysplasia without a nodule development (VI World Congress of International Society for Diseases of the Esophagus (ISDE) were included. Results. In patients of Group I a severe esophageal edema have occurred in accordance to endoscopic ultrasonography data. In this Group in 5 (13.89%) patients after performance of the argon-plasm coagulation esophageal stenosis was observed, corrected by application of the balloon dilation. In 8 (22.22%) patients of this Group the disease recurrence have occurred, necessitating performance of additional séance of the argon-plasm coagulation. In patients of Group II the above mentioned inflammatory signs were less pronounced, and mucosal regeneration have proceeded more rapidly, than in patients of Group I - during 53 and 115 days, accordingly. The disease recurrence was noted in 2 (5.41%) patients of Group II only. Conclusion. High-frequency welding of living tissues constitute a safe and effective method of treatment in patients, having esophageal metaplasia.