The authors reviewed literature on influence of occupational vibration on workers. The data presented cover changes of antioxidant, immune and hormonal state, central nervous system disorders, alterations of hemopoiesis, muscular and connective tissues.

The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.

The authors studied antioxidant therapy in complex preventive treatment of vibration disease. Findings are high therapeutic efficiency of thioctic acid — better lipid and carbohydrates metabolism parameters, endoneural circulation due to antioxidant, membrane protective, lipotropic and hypoglycemic effects.

The study presented describes formation of osteopenic syndrome in workers exposed to physical overexertion and general vibration that is associated with changes in bone metabolism and in mineral density of bone tissue. The data obtained prove bone metabolism to be influenced by pituitary and thyroid system hormones in patients with occupational lumbosacral radiculopathy.