We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and functions of the nervous system and the pathogenesis of TS and COVID-19 with emphasis on the involvement of the brain and lungs. We observed that COVID-19 worsens the course of epilepsy in patients with TS. In TS patients, lymphangioleiomyomatosis may predispose to SARS-CoV-2 invasion into the respiratory system because of the increased expression of ACE2 and TMPRSS2 in type II pneumocytes and thus may worsen the prognosis. We also review the current data on the continuation/termination of everolimus administration in patients with TS associated with COVID-19.

Severe or persistent stress can cause emotional disturbances, which worsens the human condition.  Psychological counselling is of paramount importance, however, some people may not have access to a psychologist or psychotherapist in a stressful situation and one has to resort to the medical therapy. 85 patients (mean age 26.5 ± 3.5 years) under professional stress (primary school teachers, nurses) diagnosed with “tension headaches, autonomic dysfunction” were included in the observational study.  Patients were explained the causes of the disease, given recommendations on lifestyle and prescribed Valocordin at the dosage of 15 drops 3 times a day for 3 weeks. All patients showed improvement; none of the patients reported difficulty remembering, attention failure, problems talking. 88.3% of patients showed positive effect after 6 months, 61.1% of patients after 9 months and 49.9% of patients after 12 months. Despite disagreements in the medical professional environment, Valocordin remains one of the most popular drugs in patients under stress. The short-term use of Valocordin at therapeutic doses under stress conditions effectively helps to cope with insomnia, increased anxiety, relieves nervous tension and autonomic dysfunction.

No abstract

No abstract

The novel coronavirus SARS-CoV-2 and the disease it causes, COVID-19, along with damage to the respiratory system, can lead to disorders of the central and peripheral nervous system, as well as the muscular system. The article presents literature data and the authors’ observations of the course of neurological disorders in a patient with COVID-19. This study found that there is a link between the severity of COVID-19 and the intensity and frequency of neurological disorders.