A Polyindole-ZnO nanocomposite particle was synthesized by using a chemical oxidative polymerization method. Synthesized nanocomposite was characterized by UV-Visible, FTIR, SEM, XRD, EDAX and electrical conductivity measurements. The band at $3400 cm À1 and 735 cm À1 in FTIR spectra confirmed the polyindole formation. XRD spectral studies exhibits major diffraction in between 30-40 (2h) indicates the partial crystalline nature of the polyindole-ZnO nanocomposite. SEM image reveals agglomerated granular particulate nature with ZnO embedded in the polyindole matrix. The application of Polyindole-ZnO nanocomposite as a polymer-supported catalyst was studied for the synthesis of one pot multicomponent Biginelli condensation.