The relevance of the study is dictated by the growing role of the fuel and energy complex of developing countries in the decarbonization of the economy. The article discusses the digital transformation of mining enterprises in Kazakhstan, taking into account the transition to CRIRSCO international standards and growing competition in the global mineral market. The purpose of the study is to assess the current level of digitalization of the mining industry in Kazakhstan and to deepen the methodological apparatus of the geological and economic assessment of the enterprise based on the factual base of deposits. The role of the transformation of the mining sector in achieving the sustainability of the poorly diversified economy of Kazakhstan is shown. The importance of digitalization of the industry to complete the transition to CRIRSCO international standards and improve the assessment of the digital provision of enterprises in order to optimize their financial and economic policies is argued. It has been established that, at present, most of the enterprises in the investment-attractive mining sector have a low potential for the transition to a new technological paradigm. A methodological approach to the geological and economic assessment of these enterprises has been developed. To maintain high standards of management transparency through the digitalization of key business processes, along with well-known practices of economic analysis, the IDEF1 methodology was used. In order to expand the software ecosystem, the formats of electronic geological and economic databases are integrated into the digital infrastructure of the enterprise. It is substantiated that the introduction of high technologies in the mining industry requires institutional changes and coordinated interaction between the state, business, and universities as equal partners.

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Purpose of the study. Assessment of safety and short‑term effectiveness of high and very high‑risk prostate cancer neoadjuvant chemo‑ hormonal treatment without distant metastases.Patients and methods. Combined hormone chemo‑ radiation treatment of 33 patients with prostate cancer of high and very high risk of progression without distant metastases was performed. Metastases to regional lymph nodes were found in 9 patients according to the examination data (MRI, MSCT), no metastases were detected in 24 patients. All patients underwent combined chemohormonal therapy in the amount of 4 courses of docetaxel intravenously at a dose of 75 mg/m2 every 3 weeks as the first stage of treatment. in combination with androgen deprivation therapy with agonists or antagonists of GnRH before performing radical radiation therapy (combined or remote). All patients underwent neoadjuvant hormone therapy: 16 patients – with the use of GnRH antagonists (Degarelix), 17 – with the use of GnRH agonists (Gozerelin/Leuprorelin/Triptorelin). The toxicity of the presented treatment regimen and its immediate effectiveness – the effect on the level of prostate‑s pecific antigen (PSA), prostate volume, and the quality of urination – were evaluated.Results. Treatment regimen was highly effective concerning PSA decrease (from initial median level 79,67 ng/ml to 1,45 ng/ml after neoadjuvant treatment), all subjects responded well, no non‑responders observed. Median prostate volume decreased from 44 cm3 to 25 cm3 after treatment, which guaranteed availability and safety of further radical radiation treatment. Urinary function was restored in all subject with initial urinary retention.Conclusion. Neoadjuvant chemo‑h ormonal treatment was highly effective in PSA level, prostate volume decrease and functional results improvement which secured further radical radiation treatment in one of its types. Toxicity was acceptable, adverse events did not exceed grade II in most cases and did not lead to treatment discontinuation in any cases, while quality of life remained high enough.

The article considers the problems of revising the paradigmatic framework of the development of modern economic theories. The study is based on the use of constructivist methodology, which allows studying meaningfully the processes of economic development as a complex system. The emergence of the modern paradigmatic framework of economic theories is interpreted as a result of the use of an eclectic combination of elements of individualistic and holistic methodologies. The paper considers the issues of transition to the research paradigm of studying the links between economic relations, values and institutions, taking into account the diversity of economic motives and interests of subjects, which have the ability to create collective forms of economic activity.