Blastocystis spp pathogenic potential remains controversial. Recently, many researchers have suggested the possible etiological relationship between symptomatic skin rashes and Blastocystic morphological forms, genetic diversity and microbiota interaction. A small observation series of acute and chronic urticaria caused by Blastocystic hominis in elderly patients has been herein presented. These cases emphasize the importance of adequate parasite verification under appropriate clinical settings and upon elimination of other more common causative factors as well as the significance of proper etiological treatment in urticaria patients.