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It was suggested that butadion and indomethacin, the derivatives of anthranilic acid, are capable of competitively interacting with receptors or enzymatic systems involved in the synthesis, deposition, or release of histamine and serotonin from their depots in tissues. This conclusion was based on the fact that the distance between the carboxy or enolic group and the second reaction center (hydroxy or amino group) in molecules of these antiinflammatory drugs (having an acid character) falls within 0.455-0.480 nm for anthranilic acid and 0.584 -0.667 nm for indomethacin, which corresponds to the

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