Eye is a highly vascularised organ. There are chances that a foreign substance can enter the systemic circulation through the eye and cause oxidative stress and evoke immune response. Here the eyes of rabbits were exposed, for a period of 7 days, to 5 known ocular irritants: Cetyl pyridinium chloride (CPC), sodium salicylate (SS), imidazole (IMI), acetaminophen (ACT) and nicotinamide (NIC). The eyes were scored according to the draize scoring. Blood collected from the treated rabbit were analyzed for haematological and biochemical parameters. After sacrifice, histological analysis of the eye and analysis of pro-inflammatory biomarkers (IL-1α, IL-1β, IL-8 and TNF-α) in the cornea using ELISA was carried out. Spleen was collected and the proliferation capacities of spleenocytes were analyzed. Liver and brain were collected and assessed for oxidative stress. The eye irritation potential of the chemicals was evident from the redness and swelling of the conjunctiva and cornea. Histopathological analysis and ELISA assay showed signs of inflammation in the eye. However, the haematological and biochemical parameters showed no change. Spleenocyte proliferations showed only slight alterations which were not significant. Also oxidative stress in the brain and liver were negligible. In conclusion, chemicals which cause ocular irritation and inflammation did not show any systemic side-effects in the present scenario.

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The peanut or ground nut (Arachis hypogeae L.) is a species in the legume or bean family (Fabaceae). Sesame (Sesamum indicum L.) is a flowering plant belonging to the family Pedaliaceae. The present study was carried out to study the effect of different bio-fertilizers on the chlorophyll, nitrogen content on the 30th day of growth of the plants and Vitamin E content in the seeds after harvest of the two test crops. The bio-fertilizers used were Azospirillum, panchagavya, VAM fungi and a mixture of these three fertilizers. Control plant was maintained without any fertilizer application. The chlorophyll and nitrogen content seemed to be more in the plants treated with mixture of organic fertilizers in both the plants. The Vitamin E content were found to be higher in seeds obtained from Azospirillum treated plants in groundnut and VAM fungus treated plants in sesame.

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