We studied in vitro effect of epithermal neutrons in various doses on viability of glioblastoma U87 tumor cells. Increasing the dose from 1.9 to 4.1 Sv promoted cell death. Cytofluorimetric analysis revealed no activation of apoptosis in the irradiated cells, which attested to necrotic death of the tumor cells exposed to epithermal neutron radiation.

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The time of flight technique with a new method for generating short radiation bursts has been used to measure the neutron spectrum of the accelerator based source with a stationary proton beam. Spe cific problems arising thereby and methods for solving them are described. The measured spectrum of neu trons in the reaction 7 Li(p, n) 7 Be at a proton energy of 1.915 MeV is presented and compared to the calcula tion. This spectrum is shown to comply with the requirements for the neutron beam used in neutron capture therapy.

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