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Note. Significance of differences: lp<0.01, 2p<0.001 (compared with the control); 3p<0.01, 4p<0.001 (compared with the antagonist); Sp<0.05, ~p<0.01, 7p<0.001 (compared with clonidine).

Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA(A) and GABAB antagonists separately and in combination is not below the estimated value. Therefore, GABA(A) and GABA(B) receptor mechanisms of the neuroprotective effects independently and separately contribute to the improvement of brain resistance to global ischemia.

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