Cinnamomum zeylanicum Linn. has been used as a spice and flavoring agents. It is one of the healthiest spices and possesses useful medicinal benefits. It has been recognized as the medicinally essential phytocon stituents, such as phenolic, flavonoid and carotenoid. It is loaded with rich amount of polyphenols, which are the powerful antioxidants. It inhibits the growth of certain bacteria and fungi. It dramatically reduce insulin resistance, there by helps insulin to reduce blood glucose. It also slow down the break down of carbohydrate by interfering with carbohydrate digesting enzymes and decreases the entry of glucose from intestine to bloodstream. It reduces the growth of cancer cells. Numerous pharmacological investigations have confirmed that the ability of this plant is to exhibit hepatoprotective, cardio protective, and neuroprotective activities and it supports the traditional uses. Present review gives a detailed information on recent literatures describing the multipotential uses of C. zeylanicum available for the treating various ailments.
Objective: The present study was aimed to investigate gold nanoparticles synthesized by fungal isolate Neosartorya udagawae and determination of their stability in biofluids to probe their aptness in drug delivery applications.
Methods:In this procedure, gold nanoparticles were prepared by biosynthesis using seven days old culture of Neosartorya udagawae and aqueous chloroauric acid. After the complete reaction, the fungal biomass was subjected to UV-Vis, XRD, FT-IR Spectrum analysis, TEM, Zeta potential, SEM and EDX analysis.Results: Intra/extracellular synthesis of gold nanoparticles was confirmed by a sharp peak at 526 nm in UV spectroscopy. SEM, TEM analysis demonstrates the spherical shape of AuNPs with an average diameter of 50 nm and XRD confirm the crystalline gold nanoparticles. FTIR analysis reveals the presence of the protein shell around the gold nanoparticles. The zeta potential value of AuNPs was-36mV which confirmed the stability of nanoparticles dispersion. Gold nanoparticles have shown high stability in biofluids of Bovine Serum Albumin and Phosphate Buffer Saline at pH-5, pH-7and pH-9 which mimic the human colonic biological environment.
Conclusion:The fungal synthesis of AuNPs has been experimentally demonstrated and their stability in BSA, 10% NaCl and PBS at pH-7. This might be a promising option for drug delivery applications in carcinogenic colon disorders in human beings.
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