The article analyzed treatments results of 76 patients with deep burns. It was stated that magneto-plasma therapy facilitated to the change from an inflammatory type of burn cytograms to regenerative type. These changes were expressed in reducing of neutrophil quantity in wound on the fifth day, decreasing of degenerative changed leukocytes on the tenth day, increasing of phagocytic activity of neutrophils in all terms, growing of macrophage reaction by the fifth day and multiplication of fibroblast quantity in wound on the tenth day. The neutrophil and macrophage quantities were increased in the wound after necrectomy due to influence of magneto-plasmatic therapy on the third day. There was synthesized interleukin-8. The quantity of cells producing IL-8 was reduced on the tenth day.

Aim. To develop a computer program to determine the probability of colorectal cancer based on the assessment of the levels of CTLA-4 and its ligand B7.2.Materials and methods. The study included 44 patients with colorectal cancer (CRC) and 25 patients with benign tumors of the colon. The control group consisted of 25 individuals who had been operated for colon injury. We determined the levels of CTLA-4 and B7.2 in the blood serum and in the supernatants of tumor tissue and lymph node homogenates using flow cytofluorometry.Results. We found that the level of CTLA-4 in the blood serum increased by 2.77 times in CRC patients compared to the control group (p < 0.001). The concentration of CTLA-4 in the tumor tissue in patients with CRC was 2.34 times higher than in the control group (p = 0.007). The concentration of the B7.2 ligand in the blood serum of patients with CRC exceeded this parameter in the control group by 2.51 times (p = 0.002). The concentration of B7.2 in the tumor tissue of CRC patients was 1.68 times higher (p = 0.004) than in the control group. The analysis of the obtained data determined the parameters that have prognostic value in the structure of the diagnostic model. Using these parameters, we developed a computer program to determine the probability of CRC in the patient.Conclusion. The data obtained demonstrate an increase in the levels of CTLA-4 and its ligand B7.2 in the serum and tumor tissue of patients with CRC.

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Endoscopic techique resulted good and satisfactory outcomes in 53.8% and 27% of cases within short terms. The best results were obtained in case of local post-ambustial and peptic ulcers. At the end of treatment inflammation and mitotic activity were decreased in mucosa and submucosa of the narrowed segment. Also thickness of the epithelium and stratification of tissue layers were normal. Connective tissue volume was moderately decreased in subepithelial area.

Biologically active peptides bursopeptide-1 (Tyr-Glu-Glu) and bursopeptide-2 (Trp-Thr-Ala-Glu-Glu-Lys-Gln-Leu) from the bursa of Fabricius were isolated and synthesized. Bursopeptide-1 stimulated expression of B cell differentiation antigens in lymphocyte culture from patients with burns. Bursopeptide-2 produced a variety of effects and stimulated expression of differentiation antigens on T and B cells and natural killer cells. Bursopeptides can modulate the mechanisms of interleukin-2-mediated lymphocyte activation. Bursopeptides stimulated the immune response in mice with cyclophosphamide-induced immunodeficiency, which manifested in increased hemagglutinin and hemolysin titers and increased count of antibody-producing cells in the spleen.