The article presents the results of a review devoted to the search for optimal methods of treatment in patients with epilepsy with concomitant cognitive impairments. It has been established that antiepileptic drugs with a nootropic effect are the most optimal choice in terms of compliance with the therapy, as well as reducing the frequency of side effects in the case of monotherapy in comparison with the combined use of nootropics and antiepileptic drugs. Levetiracetam is one of the drugs of choice with proven beneficial effects on cognitive function in patients with epilepsy. Due to high safety profile, it can be recommended for use in elderly patients with epilepsy, including for the termination of status epilepticus, and can also be used in cases of combination of Alzheimer’s disease with epilepsy. A promising direction for further researches is to study the possibilities of using levetiracetam in traumatic injuries of the nervous system.

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