Productive efficiency of technology of polysaccharide and lignin manufacturing from wood raw materials can be significantly improved by integration of purification stages of low molecu lar weight wood components widely used in applied chemistry into the technological cycle. In this connection, phenols including lignans and flavonoids, which have a practical application potential, are of a special interest. In the present work the results of a study of the content of (-) secoisolariciresinol, dihydroquercetin and related polyphenols in different morphological parts and anatomical structures of larch wood from the Siberia are analyzed. Analysis of the content of the listed products by reversed phase HPLC provides the selection of optimal raw material for organizing the manufacture of the listed compounds with predictable efficiency. Increased content of (-) secoisolariciresinol (up to 3-4%) observed in wood of the trunk knot areas of larch from Khakassia evidences the prospects of raw material processing in this region for production of (-) secoisolariciresinol from the wastes of larch wood refinery.