The materials of using a complex of pharmacological drugs for pigs for the prophylaxis of gastrointestinal diseases are presented in this article. Animals from the experimental group from the 23rd to the 75th day of life during 7 days received a complex of medicinal products: Brovasceptol-350 g, Ultracid-100 g, zinc oxide-100 g, Lactysan-50 g, and feed additive Starter BVMD for 100 kg of mixed fodder. The piglets of the control group received a similar feed, but without probiotic Lactysan. Brovaseptol was used in both groups for 14 days from the beginning of the experiment, and the rest of the drugs were added continuously to 75 days of life. The studies determined the increment of pigs, taking into account their preservation and conversion of feed. We used generally accepted methods for clinical examination of animals. In the blood serum of animals, the content of total protein, total calcium, inorganic phosphorus, alkaline reserve, activity of the enzymes AsAt and AlAt were determined. The obtained results were statistically processed in the Exel program.