We studied the dynamics and structure of the incidence of some infectious and parasitic diseases in Chukotka (codes for ICD-10 A00-B99) during the 2000–2017 period, the levels and structure of mortality due to some infectious and parasitic diseases. We used materials from the forms of federal statistical observation No. 2 «Information on infectious and parasitic diseases», No. 12 «Information on the number of diseases registered in patients living in the service area of the medical establishment» and materials of Russian Federal State Statistics Service. The results of the monitoring indicate an increased incidence of infectious and parasitic diseases on the territory of Chukotka Autonomous District compared to Russia. Chicken pox prevails, acute intestinal infections (mainly of unspecified etiology) followed with a significant margin. There was a sharp increase in newly detected cases of active tuberculosis in Chukotka over the last 10 years. The incidence rate in Chukotka was in 4.2 times higher in 2018 than the average ones in Russia. We suppose that the real incidence rates, especially of parasitic diseases, are even higher. Therefore, it is necessary to improve the system of diagnosis, registration of these diseases, especially in rural areas, to develop adequate measures to manage the incidence of infectious and parasitic diseases.